Use of the restrained rat technique for study of the antiulcer effect of drugs

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Abstract
Five anticholinergic drugs, atropine sulfate, diphenmethanil, mepiperphenidol, propantheline and scopolamine methiodide significantly decreased ulceration; scopolamine methiodide appeared to be the most potent drug tested, followed by propantheline, atropine, diphenmethanil and mepiperphenidol. Three central nervous system depressants, chlorpromazine, benactyzine and pentpbarbital, all decreased the incidence of ulcers with no differences in potency. Acetazolamide administered daily for 5 days had no effect on ulceration. Prednisolone administered daily increased the time required for recovery from restraint-produced ulcers.
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