Human Immunodeficiency Virus Type 1 (HIV‐1) Plasma Virus Load and Markers of Immune Activation among HIV‐Infected Female Sex Workers with Sexually Transmitted Diseases in Abidjan, Côte d'Ivoire
Open Access
- 1 May 2001
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 183 (9) , 1405-1408
- https://doi.org/10.1086/319855
Abstract
Plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA and markers of immune activation were compared among HIV-1–infected female sex workers (FSWs) with (n=112) and without (n=88) sexually transmitted diseases (STDs) in Abidjan, Côte d’Ivoire. After adjustment for CD4+ T cells, the median virus load was 2.5-fold higher among HIV-seropositive FSWs with STDs than among those without an STD (P=.053). Median virus load was higher for FSWs with a genital ulcer (P=.052) or gonorrhoea (P=.058) than for FSWs without any STD. Median levels of markers of immune activation (CD38 and HLA-DR on CD8+ T cells, soluble tumor necrosis factor–α receptor II, and β2-microglobulin) tended to be elevated, albeit nonsignificantly, among FSWs in the STD group. These findings have important public health implications in elaborating strategies for decreasing disease progression and transmission of HIV among FSWsKeywords
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