Effect of nonsteroidal anti-inflammatory drugs on the absorption of macromolecular drugs in rat rectum.

1 January 1986

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 34 (6) , 2628-2631
https://doi.org/10.1248/cpb.34.2628

Abstract

The effect of three nonsteroidal anti-inflammatory drugs (NSAID), indomethacin, phenylbutazone and diclofenac sodium, on the absorption of water-soluble drugs with various molecular weights through the rectal membrane was evaluated by using an in situ perfusion technique. 14C-Inulin, 125I-insulin, 125I-polyvinyl pyrrolidone (PVP) and 125I-albumin were selected as marked drugs. NSAID increased the absorptions of inulin, insulin and PVP, but not that of albumin. It is suggested that macromolecular drugs with a molecular weight of less than 35000 are able to penetrate through the rectal membrane in the presence of NSAID.

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