IMMUNE-RESPONSE IN SKUNKS TO A VACCINIA VIRUS RECOMBINANT EXPRESSING THE RABIES VIRUS GLYCOPROTEIN

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  • 1 July 1987
    • journal article
    • research article
    • Vol. 51  (3) , 363-366
Abstract
Striped strikes (Mephitis mephitis) were vaccinated with a vaccina virus recombinant expressing the rabies virus glycoprotein. Virus neutralizing antibodies to rabies virus were present at 14 days postvaccination by the following routes: scarification (6/6), intramuscular (4/4) and intestinal (5/8). Six out of seven skunks that ate vaccine filled baits had virus neutralizing antibodies at 28 days. When challenged intramuscularly with street virus, the survival rates were 5/7 for the bait-fed group, 4/8 for the intestinal group, 3/4 for the intramuscular group, 5/6 for the animals that were scarified, and 0/8 for controls. This is the first report of a high rate of immunization of skunk with a rabies vaccine administered orally.

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