Passive Anaphylaxis in Mice with Homologous Antiserum

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Abstract
Summary: Various factors influencing the anaphylactic reactivity of mice have been studied. There is a direct relation between the amount of antigenantibody complex injected and the severity of the anaphylactic reaction. This complex must be present at a specific level within a limited period of time for death to occur. Mice surviving an initial reaction are desensitized to subsequent lethal reactions 10 min to 6 days later, the duration depending upon the challenging dose of complex. The Webster-Swiss (W-BRVS) strain is exquisitely sensitive to anaphylactic shock when compared to several other strains. Studies on desensitization with different types of anaphylaxis using different antigen-antibody systems for desensitization and challenge suggest that the depletion of a substance other than antibody or complement is responsible for the refractory state.

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