Gas Chromatography-Chemical Ionization Mass Spectrometry of Cocaine and Its Metabolites in Biological Fluids*
- 1 January 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 4 (1) , 37-42
- https://doi.org/10.1093/jat/4.1.37
Abstract
A gas chromatographic-chemical ionization mass spectrometry (GC-CIMS) method is described tor the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficients of variation (%) are less than 10% and the method has a sensitivity of less than 5 ng/mL from 1 mL or 1 gram of sample. The procedure has been applied to a number of cases involving cocaine intoxication and analytical data from these are described.This publication has 6 references indexed in Scilit:
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- Measurement of benzoylecgonine and cocaine in urine, separation of various cocaine metabolites using reversed-phase high-performance liquid chromatographyJournal of Chromatography A, 1978
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