Aspirin Reduces Alcohol‐Induced Prenatal Mortality and Malformations in Mice
- 1 November 1984
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 8 (6) , 513-515
- https://doi.org/10.1111/j.1530-0277.1984.tb05719.x
Abstract
Oral alcohol administration (5.8 g/kg) on gestation day 10 resulted in an increase in both prenatal mortality and birth defects as well as decreased fetal weight in C57BL/BJ mice. Aspirin pretreatment (150 mg/kg subcutaneously) significantly reduced the number of malformed pups and prevented the increase in prenatal mortality produced by alcohol. The mechanism of action remains to be elucidated.This publication has 9 references indexed in Scilit:
- Antagonism of alcohol hypnosis by blockade of prostaglandin synthesis and activity: Genotype and time course effectsPharmacology Biochemistry and Behavior, 1983
- Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: Implications for the study of the fetal alcohol syndromeTeratology, 1983
- Fetal Alcohol Syndrome: Embryogenesis in a Mouse ModelScience, 1981
- Prenatal ethanol exposure in mice: Teratogenic effectsTeratology, 1979
- Prostaglandin synthetase inhibitors antagonize the depressant effects of ethanolPharmacology Biochemistry and Behavior, 1979
- The Fetal Alcohol SyndromeNew England Journal of Medicine, 1978
- The fetal alcohol syndrome in mice: An animal modelTeratology, 1977
- Teratogenic effects of ethyl alcohol administered to pregnant miceAmerican Journal of Obstetrics and Gynecology, 1976
- A rapid method for detecting malformations in rat fetusesJournal of Morphology, 1969