Effect of Surfactants on Surface Structure in Liquid Chromatography

Abstract
The chromatographic performance of hydrophobically modified silica (i.e., octyl and octadecyl surfaces) in contact with aqueous mobile phases containing one of four linear alkyl anion surfactants is examined. Log-log plots of k′ vs. concentration of surfactant in the mobile phase shows three distinct trends. Initially, solute retention changes little with increasing amounts of surfactant. However, a dramatic decrease in solute retention occurs prior to micelle formation and may be due to changes in the surface's structure-solvation.

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