Directly compressed tablets containing chitin or chitosan in addition to mannitol.

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Abstract
As a part of a series of studies on pharmaceutical applications of chitin and chitosan, the fluidity and compressibility of combined powders of mannitol with chitin and chitosan, as well as the disintegration properties of tablets made from these powders were investigated in comparison with those of crystalline cellulose with mannitol. The fluidity of the combined powders with chitin and chitosan was a little greater than that of the powder with crystalline cellulose. At more than 30% addition of chitin, chitosan or crystalline cellulose, tablets were easily formed. Tablets containing less than 60% chitin or chitosan passed the disintegration test of JP X. It is suggested that chitin and chitosan, as well as crystalline cellulose, may be suitable as diluents for chewable, sublingual or oral mucosal tablets prepared by direct compression processes.

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