RESPONSE OF THE ADRENAL MEDULLA TO EXOGENOUS INSULIN IN HEAD X-IRRADIATED DOGS

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Abstract
Department of Pathophysiology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki 852, Japan (Received 25 May 1976) In a previous study (Yamashita, Shimizu & Waki, 1972), there was a decreased response of the adrenal medulla to acetylcholine after exposure of the adrenal area to moderate doses of X-rays. In this paper, we present the results observed on the secretory response of the adrenal medulla to exogenous insulin in dogs whose heads had been irradiated with lower doses of X-rays. Adult mongrel dogs weighing 8·9–13·9 kg were used. The animals received 200 rad X-irradiation to their heads under pentobarbitone anaesthesia. Radiation was delivered at a rate of 60·6 rad/min, using a therapy unit (200 kV, 30 mA) with a filter comprising 1·5 mm copper– 0·5 mm aluminium. Target-to-skin distance was 37 cm. Approximately 18 h after irradiation, the animals were re-anaesthetized with pentobarbitone (25 mg/kg, injected i.v.) and the left

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