Effect of diazepam and chlordiazepoxide on the metabolism of other drugs

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Abstract
Diazepam and chlordiazepoxide, even at high single doses, do not inhibit the metabolic transformation of p-nitroanisol, aniline and aminopyrine by the 9,000 g fraction of rat liver. Although diazepam and chlordiazepoxide increase the sleeping time induced by pentobarbitone, this effect is not explained by an increase in the brain level of pentobarbitone. Repeated administrations of the two benzodiazepines increase the metabolism of p-nitroanisol, aniline, amidopyrine and shorten the sleeping time induced by pentobarbitone in rats. There was a concomitant reduction of the concentration of brain pentobarbitone.