Plasma membrane requirements for cell fusion induced by herpes simplex virus type 1 glycoproteins gB, gD, gH and gL
- 1 June 2001
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 82 (6) , 1419-1422
- https://doi.org/10.1099/0022-1317-82-6-1419
Abstract
Herpes simplex virus type 1 (HSV-1) glycoproteins gB, gD and gHL are capable of inducing cell fusion when expressed from plasmid vectors in the absence of any other virus components. Fusion requires the expression of all four glycoproteins on the same membrane, since they are unable to cooperate in trans to induce syncytium formation. In addition, the fusion event is dependent on the expression of a gD receptor on target cell membranes and does not require the presence of cell-surface glycosaminoglycans.Keywords
This publication has 35 references indexed in Scilit:
- Assembly and Organization of Glycoproteins B, C, D, and H in Herpes Simplex Virus Type 1 Particles Lacking Individual Glycoproteins: No Evidence for the Formation of a Complex of These MoleculesJournal of Virology, 2001
- Characterization of cell–cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cellsJournal of General Virology, 2000
- Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)Journal of Virology, 2000
- A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 EntryCell, 1999
- Entry of alphaherpesviruses into cellsSeminars in Virology, 1993
- Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deletedJournal of Virology, 1992
- Modulation of cell surface heparan sulfate structure by growth of cells in the presence of chlorateBiochemistry, 1989
- A viable HSV-1 mutant deleted in two nonessential major glycoproteinsVirology, 1989
- Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusionJournal of Virology, 1988
- A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cellsJournal of Virology, 1988