The Action of Synthetic Detergents Upon Certain Strains of Bacteriophage and Virus

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Abstract
Summary: A comparison of the inactivation pattern obtained with a group of 20 detergents and germicides against influenza A and vaccinia viruses and three bacteriophage strains revealed marked differences in the susceptibility of the several viruses. Gamma phage active against Escherichia coli B was found to be resistant to all the test agents, differing in this respect from the other viruses tested. A group of eight glycolytic inhibitors failed to prevent the growth of vaccinia virus on the chorio-allantoic membrane. The addition of the compounds to the mouse lung appeared to stimulate the growth of influenza A virus. Igepon AP, a non-toxic anionic detergent inert against bacteria and viruses, was found, in high dilution, to inhibit the growth of vaccinia virus.

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