All-Night Polygraphic Recordings on the Hypnotic Effects of a New Benzodiazepine: Flunitrazepam (Ro 5–4200, Rohypnol®)

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Abstract
The authors present an all-night polygraphic cooperative study on a new benzodiazepine: Flunitrazepam (Ro 5–4200). The drug was administered (alternatively with placebo) for at least 8 subsequent nights to 6 normal subjects and to 6 insomniacs. Ro 5–4200 significantly increased the total time and decreased the latency of sleep and the number of awakenings. No significant effects on sleep stages and no remarkable side effects were observed.

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