Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions
Top Cited Papers
- 11 April 2008
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 320 (5873) , 230-233
- https://doi.org/10.1126/science.1153201
Abstract
Cytidine deaminases of the APOBEC3 family all have specificity for single-stranded DNA, which may become exposed during replication or transcription of double-stranded DNA. Three human APOBEC3A (hA3A), hA3B, and hA3H genes are expressed in keratinocytes and skin, leading us to determine whether genetic editing of human papillomavirus (HPV) DNA occurred. In a study of HPV1a plantar warts and HPV16 precancerous cervical biopsies, hyperedited HPV1a and HPV16 genomes were found. Strictly analogous results were obtained from transfection experiments with HPV plasmid DNA and the three nuclear localized enzymes: hA3A, hA3C, and hA3H. Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors.Keywords
This publication has 29 references indexed in Scilit:
- All APOBEC3 family proteins differentially inhibit LINE-1 retrotranspositionNucleic Acids Research, 2007
- Cellular inhibitors of long interspersed element 1 and Alu retrotranspositionProceedings of the National Academy of Sciences, 2006
- A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteinsThe EMBO Journal, 2004
- APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptaseNucleic Acids Research, 2004
- Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by VifCell, 2003
- DNA Deamination Mediates Innate Immunity to Retroviral InfectionCell, 2003
- The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNANature, 2003
- Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcriptsNature, 2003
- Hypermutation of HIV-1 DNA in the Absence of the Vif ProteinScience, 2003
- Psoriasis Upregulated Phorbolin-1 Shares Structural but not Functional Similarity to the mRNA-Editing Protein Apobec-1Journal of Investigative Dermatology, 1999