A One-Step Synthesis of Alkyl 2-Oxo-3-alkenoates from Alkenyl Grignard Reagents and Dialkyl Oxalates
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (07) , 564-566
- https://doi.org/10.1055/s-1988-27642
Abstract
The reaction of alkenyl Grignard reagents with dialkyl oxalates at 80°C in an ether/tetrahydrofuran mixture (1:1) leads to the formation of the corresponding alkyl 2-oxo-3-alkenoates in high yields. Thus a mild and convenient one-step synthesis of 3-isopropenyl-substituted 2-oxoesters is described.Keywords
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