THE EFFECT OF ECLAMPTIC BLOOD UPON THE URINARY OUTPUT AND BLOOD PRESSURE OF HUMAN RECIPIENTS

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Abstract
400 cc. of blood were rapidly transferred from patients with eclampsia or severe preeclampsia to normal, well hydrated puerperal women and the effects on the blood pressures and rates of urine output noted. No pressor or anti-diuretic substance could be detected by these methods. Transfusions of normal blood produced similar results. Normal blood plus small amts. of pituitrin had antidiuretic effects. Blood obtained from donors who received pituitrin did not inhibit diuresis. Amts. of pituitrin as low as 0.01 unit may be readily detected on suitably prepared human test subjects. 400 cc. of eclamptic blood evidently does not contain the equivalent of 0.01 unit of active postpituitary hormone, nor significant amts. of "toxins" or pressor substance.