PENICILLIN IN TETANUS

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Abstract
Tetanus, or lockjaw, is one of the most dreaded infectious complications of wounds. Although its specific etiology has been known for sixty years and its diagnosis has been relatively easy, the treatment of tetanus, once established, is still unsatisfactory and the results are uncertain. It has been disappointing to see the failure of large doses of antitetanic serum to alter the course or lower the mortality of this disease once it has developed, particularly since a small dose of the antitetanic serum has been so effective in preventing the development of the disease when given prophylactically at the time of injury. This has been particularly true in the cases with incubation periods of less than six days. The studies of Abel and Firor1 have revolutionized the concept of the pathogenesis of tetanus and crystallized the facts known regarding the value and limitations of active therapy of established tetanus. Firor

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