The pharmacokinetics of ciprofloxacin in patients with impaired renal function
- 1 July 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 16 (1) , 87-93
- https://doi.org/10.1093/jac/16.1.87
Abstract
Pharmacokinetics of ciprofloxacin after single oral administration of 250 mg were studied in patients with and without renal failure. Ciprofloxacin concentrations were measured by HPLC. The elimination half-life was 8·7±0·9 h (mean±S.E.M.) in six renal failure patients not on haemodialysis, as compared to 4·4±0·2 h in six patients with normal renal function. The uninary recovery of unchanged ciprofloxacin was 5·3±1·7% of dose over 24 h in the renal failure patients, as compared to 37·0±3·7% in the patients with normal renal function. In haemodialysis patients, the half-life was 5·8±0·9 h on an interdialysis day, and 3·2±0·4 h during haemodialysis.Keywords
This publication has 2 references indexed in Scilit:
- Pharmacokinetics and tissue penetration of ciprofloxacinAntimicrobial Agents and Chemotherapy, 1983
- In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agentsAntimicrobial Agents and Chemotherapy, 1983