THE STATE OF THE STERNAL BONE MARROW

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Abstract
Normal hematopoiesis depends among other things on the formation of an antianemic factor, which comes from the interaction of an intrinsic factor found in the gastric juice and an extrinsic factor present in the diet.1 The antianemic factor when produced is apparently stored in the liver.2 If there is a lack of intrinsic factor or extrinsic factor, or if there is disease of the liver so that the antianemic factor is not stored, macrocytic anemia will develop. The macrocytic anemia of sprue has been studied; and the relationship between it and true pernicious anemia, both from the point of view of a lack of essential factors and the similarity of the bone marrow in relapse, has been emphasized.3 Clinical studies have shown that in the macrocytic anemia of pregnancy there is a temporary lack of the intrinsic or the extrinsic factor.4 This brings about a blood

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