PROGESTERONE CONCENTRATION, INTRALUMINAL PRESSURE AND ELECTRICAL ACTIVITY OF THE GUINEA-PIG UTERUS

Publisher Website
Google Scholar
Abstract
SUMMARY The electrical activity of the myometrium and the intra-uterine pressure were recorded by means of suction electrodes and intraluminal balloons respectively from anaesthetized, oestrogen-primed, ovariectomized guinea-pigs treated with progesterone (25 mg, s.c. twice, 16 h apart). No loss of intra-uterine pressure occurred after progesterone treatment and electrical activities in the balloon-containing and intact horns were indistinguishable. Furthermore, the concentration of progesterone in the uteri of these animals was 0·32 ± 0·05 (S.E.M.) μg (balloon-containing horn) and 0·43 ± 0·06 μ/g wet tissue (intact horn). These values greatly exceed the levels found in uteri of pregnant animals (0·07 ± 0·03 μ/g wet tissue). Thus the failure of progesterone to reduce myometrial activity in the guinea-pig is real and is not due to interference from the balloon, or to failure of the steroid to reach the uterine muscle or to lack of oestrogen priming.

This publication has 0 references indexed in Scilit: