Effect of Methyl Testosterone Treatment on Muscular Performance and the Central Nervous System of Older Men

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Abstract
In 6 [male] subjects between 48 and 67 yrs. of age, complaining of fatigability but without clinical symptoms, oral treatment with 30 to 40 mg. methyl testosterone increased significantly, compared to a placebo period, the fusion frequency of flicker and back-muscle strength. The performance was increased in dynamic and static work in 4 of 5 subjects. No effect was noted on the strength of arm extensors and only a slight increase of questionable significance in handgrip strength in 2 of 6 subjects. The positive effect on the fusion frequency, back-muscle strength or dynamic-work and static-work performance was maintained up to 8 mos. A dosage of 20 mg. was sufficient to maintain the effect previously attained with 40 mg. in 1 subject and was insufficient in another. No effect was observed in maximum tapping rate and heart rate in exercise and recovery. The results appear to be compatible with the hypothesis that maintenance of a higher level of [male] sex hormone has an influence on the depression of working capacity with age.

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