Studies on Heterocyclic Compounds. IV. Geometrical Isomers of 2-(2, 6-Dichlorobenzylidenehydrazino)-1, 4, 5, 6-tetrahydropyrimidine Hydrochloride and Its Related Hydrazones
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 96 (2) , 125-131
- https://doi.org/10.1248/yakushi1947.96.2_125
Abstract
The structure of a mild and durable antihypertensive agent, 2-(2,6-dichlorobenzylidenehydrazino)-1,4,5,6-tetrahydropyrimidine hydrochloride (IIIa) (OT-24), was established by nuclear Overhauser effect experiments. The anti-isomer (IIIa) easily isomerized to the syn-isomer by UV irradiation on aqueous and methanol solution. Several related hydrazones were synthesized and their configuration was examined.This publication has 0 references indexed in Scilit: