Practical and Useful Methods for the Enantioselective Reduction of Unsymmetrical Ketones
- 1 January 1992
- journal article
- review article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (07) , 605-617
- https://doi.org/10.1055/s-1992-26174
Abstract
Enantioselective reduction of unsymmetrical ketones to optically active alcohols is very important in organic synthesis. Catalytic methods have been developed for this process and have not been reviewed previously. In this article the recently developed oxazaborolidine catalyzed reduction along with other useful reagents will be discussed. 1. Introduction 2. Oxazaborolidines 3. B-3-pinanyl-9-borabicyclo[3.3.1]nonane 4. Chlorodiisopinocampheylborane 5. 2,5-Dimethylborolane 6. BINAL-H 7. BINAP-Ru Complex 8. ConclusionKeywords
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