Animal Evaluation of a New Pericardial Bioprosthetic Heart Valve

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Abstract
Implantation in animals is an essential step in the evaluation of any new prosthetic heart valve before commencing clinical trials. A new three‐leaflet pericardial bioprosthesis developed in Glasgow has been implanted in the mitral position in ten sheep and eight dogs. Eleven animals were electively killed after 3 months of observation and explanted valves were in good condition. Hydrodynamic tests of the explanted valves showed small changes in function compared to tests prior to implantation. This was mainly due to host tissue ingrowth over the edge of the leaflets. Histological studies confirmed good preservation of the pericardial tissue in explanted valves.

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