SYNTHESES OF GESTODENE

  • 1 January 1986
    • journal article
    • research article
    • Vol. 36-1  (5) , 781-783
Abstract
The synthesis of the new progestogen, 17.alpha.-ethinyl-17.beta.-hydroxy-18-methyl-4,15-estradien-3-one (gestodene, 6) starting from 18-methyl-4-estren-3,17-dione (1) can be accomplished by several methods. The oral progestational activity of gestodene is greater than that of levonorgestrel. Gestodene, in combination with ethinylestradiol, is contained in a recently developed oral contraceptive.

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