Stimulation of the globus pallidus in Parkinson's disease
- 1 January 1995
- journal article
- Published by Taylor & Francis in British Journal Of Neurosurgery
- Vol. 9 (4) , 505-510
- https://doi.org/10.1080/02688699550041142
Abstract
In 62 patients undergoing posteroventral pallidotomy (PVP) for the treatment of Parkinson's disease, we have demonstrated significant (p < 0.01) elimination of akinetic features and other symptoms during intraoperative stimulation trials in areas anterior to the PVP target (n = 30). Stimulation in anterior pallidal regions frequently resulted in an immediate reversal of akinetic states despite enforced abstinence of medications. The beneficial effects were achieved with as little as 0.25 V at 100 Hz. Stimulation at the PVP target site (n = 32) resulted in insignificant changes (p > 0.05).Keywords
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