Two problems in prescribing medication for alcoholics are that the patients may fail to take the medication or, if given large quantities to take home, may use the medications to attempt suicide. To overcome these difficulties, a long-acting phenothiazine, flufenazine enanthate, was given biweekly (25 mg in a 1-ml preparation, by intramuscular injection) to 34 alcoholics (9 women). Of the 34, 26 showed a beneficial pharmacological response to the drug; they felt more relaxed, contented, and their anxieties were relieved. The patients also responded favorably to the procedure of receiving an intragluteal injection. The drug tended to produce a number of extrapyramidal side effects but these were prevented or controlled either with benztropine or trihexphenidyl. It is concluded that a drug of this type is of potential value in treating alcoholics.