1,3,5-Trinitrobenzene-Induced Alpha-2u-Globulin Nephropathy
Open Access
- 1 March 1997
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 25 (2) , 195-201
- https://doi.org/10.1177/019262339702500209
Abstract
Male and female Fischer-344 (F-344) and male NCI-Black-Reiter (NBR) rats were dosed with 0, 35.5, or 71 mg 1,3,5-trinitrobenzene (TNB)/kg/day for 10 days. Male F-344 rats were dosed with TNB (0 and 35.5 mg/kg) for 20 and 30 days. Hematoxylin and eosin and Mallory-Heidenhain stains and alpha-2u-globulin and proliferating cell nuclear antigen immunohistochemical stains were performed on kidney sections. All treated male F-344 rats exhibited dose-related accumulation of hyaline droplets containing alpha-2u-globulin in proximal tubules. The kidney weights were significantly increased in male and female rats treated with TNB. Significant increases in cell proliferation in proximal tubules were observed in male F-344 rats. Renal changes observed in TNB-treated rats appeared identical to those from other chemicals that induce alpha-2u-globulin nephropathy in male rats. No hyaline droplet accumulation was found in female F-344 and male NBR rats at any doses. We can conclude that TNB induces dose-related exacerbation of hyaline droplets containing alpha-2u-globulin in male rat kidney and subsequent cell proliferation.Keywords
This publication has 43 references indexed in Scilit:
- Assessment of Binding of 2,4,4-Trimethyl-2-Pentanol to Low-Molecular-Weight Proteins Isolated from Kidneys of Male Rats and HumansToxicology and Applied Pharmacology, 1993
- A comparison of European High Test gasoline and PS-6 unleaded gasoline in their abilities to induce α2u-globulin nephropathy and renal cell proliferationToxicology Letters, 1992
- ?2u-Globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl)cyclohexaneacetic acidToxicology and Applied Pharmacology, 1991
- NCI-Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce ?-2u-globulin (?2u) nephropathy*1Fundamental and Applied Toxicology, 1991
- Lindane induces nephropathy and renal accumulation of α2u-globulin in male but not in female Fischer 344 rats or male NBR ratsToxicology Letters, 1990
- Loss of Androgenic Induction of α2u-Globulin Gene Family in the Liver of NIH Black Rats*Endocrinology, 1989
- Involvement of reversible binding to α2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicityToxicology and Applied Pharmacology, 1989
- Localization of alpha 2u-globulin within protein droplets of male rat kidney: immunohistochemistry using perfusion-fixed, GMA-embedded tissue sections.Journal of Histochemistry & Cytochemistry, 1989
- A Review of Unique Male Rat Hydrocarbon NephropathyToxicologic Pathology, 1986
- A Rapid One-Step Mallory-Heidenhain Stain for Connective TissueStain Technology, 1950