ORAL DISODIUM CROMOGLYCATE IN FOOD ALLERGY.

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Abstract
The effect of DSCG [disodium chromoglycate] solution per os was studied in 4 infants with immediate hypersensitivity reaction to cow''s milk and egg, manifested by digestive and cutaneous symptoms. Previous administration of a 1 per cent DSCG solution by mouth resulted in diminution of the digestive and cutaneous symptoms associated with allergen challenge. The best time interval between oral DSCG and the allergen challenge was about 30 min. The drug lost effectiveness when the solution was prepared more than 1 wk in advance of its administration. A 2 yr follow-up in 2 of the patients revealed the reappearance of cutaneous and digestive symptoms and, for the 1st time, the onset of wheezing while continuing to administer the allergens and despite continuous oral DSCG. The characteristics of these cases raise questions about the means of sensitization, and the possible mechanism of action of oral DSCG in the inhibition of non-digestive symptoms. Clinical indications for its use are discussed.