Sideroblasts, Siderocytes, and Sideroblastic Anemia

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Abstract
SMALL iron-containing granules, demonstrable by means of the Prussian blue reaction, have been recognized in erythrocytes and their precursors for at least 30 years.1 2 3 4 5 Only recently, through the use of electron microscopy,6 7 8 have two distinct series of iron-containing erythroid cells been distinguished: one in which the iron consists of cytoplasmic aggregates of ferritin and the other in which non-ferritin iron is contained within mitochondria (Table 1). The physiologic and pathologic implications of each are quite different, and the non-heme iron pools are disposed of in different ways.The purpose of this report is to describe the various types of iron-containing . . .

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