AMIODARONE-INDUCED VENTRICULAR-FIBRILLATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 11  (5) , 381-385
Abstract
Amiodarone, 600 mg orally daily, was used to control supraventricular tachyarrhythmias in a patient with the sick sinus syndrome. Twenty days from the onset of therapy the Q-T interval lengthened. Episodes of ventricular flutter, ventricular fibrillation and self-terminating ventricular tachyarrhythmia (torsade de pointes) developed on the 28th day of amiodarone therapy. Temporary cardiac pacing prevented further episodes of ventricular fibrillation. Despite the suggestion that this drug may be given in large doses for long periods of time since it has a wide safety margin, the risk of lethal arrhythmias is such that caution is required in its use.

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