High performance liquid chromatographic determination of fluvoxamine in human plasma
- 1 July 1989
- journal article
- research article
- Published by Wiley in Biomedical Chromatography
- Vol. 3 (4) , 177-179
- https://doi.org/10.1002/bmc.1130030408
Abstract
A method has been developed for the separation and measurement of fluvoxamine in human plasma by high performance liquid chromatography. The method uses metapramine as an internal standard and provides a limit of detection of about 1.5 ng/mL for fluvoxamine. At a concentration of 25 ng/mL, fluvoxamine could be measured within a coefficient of variation of ±5.82 of the mean and at 100 ng/mL within a CV of ±2.78 of the mean. The method has been applied to the analysis of plasma from patients undergoing fluvoxamine therapy.Keywords
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