BLOOD CONCENTRATION UNDER THE INFLUENCES OF AMYTAL AND URETHANE

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Abstract
Blood drawn from dogs before and during anesthesia was analyzed for refractive index of plasma, hematocrit, specific gravity of plasma and of whole blood, and dry residue of plasma and of whole blood. After sodium amytal both whole blood and plasma were greatly diluted, and after ethyl urethane both were greatly concentrated. With either the effect was greater when given by peritoneum than when given by stomach. After either the arterial blood pressure decreased and the heart rate increased. The spleen contained much more blood under amytal than under urethane. After either the blood contained in the spleen was equally concentrated with respect to corpuscles; the plasma was always the same as that in the circulation. But the corpuscles stored in the spleen were sufficient to account for only a small part of the change in concn. This was further borne out by the appearance of similar changes in the circulating blood of the splenectomized dog. Under urethane not only water but also protein left the plasma; this indicated a change of permeability to proteins in the blood capillaries.

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