HYPOTHESIS FOR THE MECHANISM OF ACTION OF CHYMOTRYPSIN
- 15 November 1957
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 43 (11) , 969-975
- https://doi.org/10.1073/pnas.43.11.969
Abstract
An interesting and provocative hypothesis for the detailed mechanism of action of chymotrypsin can be developed on the basis of the assumption that the protein near the active site in the enzyme is arranged in an alpha helix. Although this assumption is unproved, the mechanism derived from it fits most of the known data and is specific in its predictions. The essential points of the mechanism are illustrated by a model.This publication has 14 references indexed in Scilit:
- PHOSPHOPEPTIDES FROM ACID-HYDROLYZED P32-LABELED DIISOPROPYLPHOSPHORYL CHYMOTRYPSINJournal of Biological Chemistry, 1957
- The chemical structure of the reactive group of esterasesBiochimica et Biophysica Acta, 1956
- The catalysis of the hydrolysis of p-nitrophenyl acetate by imidazole and its derivativesArchives of Biochemistry and Biophysics, 1956
- THE INFLUENCE OF pH ON THE KINETIC CONSTANTS OF α-CHYMOTRYPSIN-CATALYZED ESTEROLYSISJournal of Biological Chemistry, 1956
- ACETYL CHYMOTRYPSIN AND ITS REACTION WITH ETHANOLJournal of Biological Chemistry, 1956
- Two steps in the reaction of chymotrypsin with acetyl-l-phenylalanine ethyl esterBiochemical Journal, 1955
- [Amino acid sequence in the area of the reactive serine group of the chymotrypsin molecule].1955
- A search for specific chemical methods for fission of peptide bonds. 1. The N-acyl to O-acyl transformation in the degradation of silk fibroinBiochemical Journal, 1952
- The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chainProceedings of the National Academy of Sciences, 1951
- STRUCTURAL REQUIREMENTS OF SPECIFIC INHIBITORS FOR α-CHYMOTRYPSINJournal of Biological Chemistry, 1949