Leukemic Karyotype in CFU-C of a Patient with Acute Myelomonocytic Leukemia

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To the Editor: The report by Reid et al. (June 2 issue)1 on a cytogenetic analysis of single colonies (CFU-C) grown in culture from the bone marrow of a patient with acute myelomonocytic leukemia in partial remission indicates that part of the colonies showed a "leukemic karyotype." Their study demonstrates that each colony was "monoclonal." They conclude that in this patient the "leukemic karyotype" was present in "normal" granulocyte/macrophage progenitor cells, on the basis of the absence of leukemic-blast contamination.We cannot agree with the latter statement. For many years we have been studying the blood and bone marrow of . . .