Morphogen Gradient from a Noisy Source

Preprint

24 February 2005

preprint
Published by arXiv in arXiv

https://doi.org/10.48550/arXiv.q-bio/0502036

Abstract

We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.

Keywords

NUMERICAL SIMULATION
PERTURBATION THEORY
MORPHOGEN GRADIENT
DEVELOPING EMBRYO
MODEL OF ROBUST
DEPENDENT NOISE
NOISY SOURCE
EMBRYO

All Related Versions

Version 1, 2005-02-24, ArXiv
Published version: Physical Review Letters, 94 (7), 078101.

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