Studies on peptides. CIX. Synthesis of the octatriacontapeptide corresponding to positions 1 to 38 of human parathyroid hormone.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 30 (5) , 1706-1717
- https://doi.org/10.1248/cpb.30.1706
Abstract
The octatriacontapeptide corresponding to positions 1-38 of human parathyroid hormone (hPTH), a half of the whole molecule, was synthesized by assembling 9 peptide fragments in a conventional manner. Arg(mesitylene-2-sulfonyl), a new arginine derivative bearing an acid-labile protecting group, was employed in combination with a new deprotecting procedure with 1 M trifluoromethanesulfonic acid-thioanisole in TFA [trifluoroacetic acid]. The synthetic peptide exhibited an activity of 1400 IU/mg when assayed by the mouse bone adenyl cyclase activity assay.This publication has 2 references indexed in Scilit:
- Total synthesis of bovine pancreatic ribonuclease A. Part 3. Synthesis of the protected hexapentacontapeptide ester (positions 69–124)Journal of the Chemical Society, Perkin Transactions 1, 1981
- APPROACH TO SPECIFIC CLEAVAGE OF PEPTIDE BONDS .2. SPECIFIC CLEAVAGE OF PEPTIDE CHAINS BASED ON HYDROGEN FLUORIDE-INDUCED NITROGEN TO OXYGEN ACYL SHIFT1964