INHIBITION AND ENHANCEMENT OF AVIAN ADENOVIRUS PLAQUE PRODUCTION BY HEAVY AND LIGHT AVIAN ADENOVIRUS-ASSOCIATED VIRAL PARTICLES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (4) , 549-551
Abstract
The effect of heavy and light avian adenovirus-associated viral (A-AV) particles on the replication of several adenovirus serotypes was studied in chicken embryo kidney cells. There was a significant decrease (P < 0.05) in the number and size of adenovirus-induced plaques at A-AV multiplicities of infection greater than 40. Enhancement of plaque production was observed when A-AV multiplicities of infection were 1-40. There was a significant increase in the number and size of infective centers. Analysis of cellular yields indicated an increase in the number of adenoviruses produced per cell. Heavy A-AV particles of buoyant density 1.42 g/cm3 in CsCl enhanced plaque production more than light particles (1.38 g/cm3). Conversely, light particles showed greater inhibition of plaque production. Adenovirus serotypes varied in their response to enhancement or inhibition by A-AV particles of different density.