Bence Jones Proteins: Malignant or Benign?

Publisher Website
Google Scholar
Abstract
Over a century elapsed between Henry Bence Jones' discovery of a urinary protein with unusual thermal properties in patients with multiple myeloma1 and Edelman and Gally's demonstration2 that this curious protein was the light polypeptide portion (kappa or lambda chain) of the immunoglobulin molecule. It is now known that normal urine contains very small amounts of a mixture of free kappa and lambda light chains of polyclonal origin, but Bence Jones proteinuria denotes the presence of a monoclonal light chain of either the kappa or the lambda type.Bence Jones proteins, far from being a laboratory curiosity, are historically among . . .

This publication has 11 references indexed in Scilit: