Chemosterilant Effect of 5-Fluoroorotic Acid on House Flies1

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Abstract
When fed to adult house flies, Musca domestica L., at a level of 1.0% for 48 hours after emergence, 5-fluoroorotic acid was found to be a permanent sterilant, eliminating oviposition. Although oviposition was greatly reduced at lower concentrations, a significant percentage of the eggs hatched and normal-appearing second generation flies were reared. Five-fluoroorotic acid-2-C14 was incorporated into the ovaries for 48 hours after removal of the chemical from the diet. But the testes did not at any time contain a significant quantity of the labeled 5-fluoroorotic acid.

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