The Effects of Hydrocortisone and Estrogen on Experimental Fever Induced by Etiocholanolone

Publisher Website
Google Scholar
Abstract
The effects of hydrocortisone and estrogen on experimental etiocholanolone fever were studied. Hydrocortisone given either orally, iv, or im in a different site from etiocholanolone had no significant effect on the febrile responses of normal men and women. When the hydrocortisone was given in the same site as the etiocholanolone, there was significant reduction in fever. These results suggest that the local inflammatory reaction is essential to the pyrogenicity of etiocholanolone. Nine women without ovarian function were given estrogen, and their febrile responses to etiocholanolone and endotoxin were measured. After treatment with estrogen the responses to etiocholanolone were significantly less, but no difference in the pyrogenic reactivity to endotoxin was detected. These studies demonstrate that estrogens are not nonspecific antipyretic agents and that the previously observed diminished febrile responsiveness of normal young women to etiocholanolone may be due, in part, to estrogens.

This publication has 0 references indexed in Scilit: