Total body irradiation: a neuropsychological risk factor in pediatric bone marrow transplant recipients

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Abstract
Bone marrow transplantation (BMT) involves conditioning with cyclophosphamide and, for leukemic patients, total body irradiation (TBI). Based on the concern that this may lead to later neuropsychological impairment in children, a longitudinal study was conducted. Thirty pediatric bone marrow transplant recipients, treated for leukemia or severe aplastic anemia (SAA), and their sibling donors, were given a neuropsychological examination in 1986 and 1988. A third follow‐up study of patients treated before 12 years of age was undertaken in 1990‐91. We present longitudinal data on patients treated with BMT when 3‐11 (n= 15) and 12‐17 (n= 11) years old. No neuropsychological deficits were found in the older group, or among non‐irradiated SAA patients. In the first follow‐up, children treated with BMT, including TBI at 3‐11 years of age, performed less well than donors on tasks involving perceptual and fine‐motor speed. In the second follow‐up, this group of patients also demonstrated a slight deficit in non‐verbal problem solving. An additional relative decline in verbal reasoning was noted in the third follow‐up, 5.5‐10 years after treatment. Alertness to signs of developmental difficulties in children treated with BMT, including TBI, is recommended.