Multivesicular release and saturation of glutamatergic signalling at retinal ribbon synapses
- 21 March 2007
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 580 (1) , 23-29
- https://doi.org/10.1113/jphysiol.2006.125302
Abstract
Pronounced multivesicular release (MVR) occurs at the ribbon synapses of sensory neurones that signal via graded potential changes. As MVR increases the likelihood of postsynaptic receptor saturation, it is of interest to consider how sensory synapses overcome this problem and use MVR to encode signals of widely varying intensities. Here, I discuss three postsynaptic mechanisms that permit three different retinal synapses to utilize MVR.Keywords
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