PREVALENCE OF MICROSCOPIC TUMORS IN NORMAL APPEARING RENAL PARENCHYMA OF PATIENTS WITH HEREDITARY PAPILLARY RENAL CANCER
- 1 February 2000
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 163 (2) , 431-433
- https://doi.org/10.1016/s0022-5347(05)67893-7
Abstract
Conclusions The basophilic papillary histology characteristic of clinically apparent renal tumors in patients with hereditary papillary renal cancer also characterizes the multiple microscopic lesions seen in the kidneys. These findings suggest that the earliest renal tumor in patients with an activating hereditary mutation of the met gene is papillary basophilic renal cancer. The large number of microscopic tumors in patients with hereditary papillary renal cancer was comparable to or greater than that seen in those with von Hippel-Lindau disease.Keywords
This publication has 13 references indexed in Scilit:
- Hereditary and Sporadic Papillary Renal Carcinomas with c-met Mutations Share a Distinct Morphological PhenotypeThe American Journal of Pathology, 1999
- RENAL CANCER IN FAMILIES WITH HEREDITARY RENAL CANCER: PROSPECTIVE ANALYSIS OF A TUMOR SIZE THRESHOLD FOR RENAL PARENCHYMAL SPARING SURGERYJournal of Urology, 1999
- Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomasNature Genetics, 1998
- Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasNature Genetics, 1997
- Original Articles: Kidney Cancer: Hereditary Papillary Renal Cell Carcinoma: Clinical Studies in 10 FamiliesJournal of Urology, 1995
- Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancerPublished by American Medical Association (AMA) ,1995
- Mutations of the VHL tumour suppressor gene in renal carcinomaNature Genetics, 1994
- Hereditary Papillary Renal Cell CarcinomaJournal of Urology, 1994
- Molecular differential pathology of renal cell tumoursHistopathology, 1993
- Histopathology and Classification of Renal Cell Tumors (Adenomas, Oncocytomas and Carcinomas)Pathology - Research and Practice, 1986