Glucose‐6‐Phosphate Dehydrogenase Deficiency and Blood Transfusion

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Abstract
Seven White American male blood donors with Italian surnames were found to have red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency among 1,285 with Greek or Italian surnames screened. Five different genetic variants were found: G‐6‐PDs Mediterranean (2), ‘Athens‐like’ (2), San Juan, Columbus and ‘Canton‐like’. Clinical evaluation of 23 patients who received 24 units of G‐6‐PD‐deficient blood (G‐6‐PD A‐) failed to reveal any deleterious effects. Screening of Black donors for G‐6‐PD deficiency is believed unnecessary; further data are needed before a recommendation can be made concerning screening for non‐Black donors.