0.05% Clobetasol 17-Propionate Cream and Ointment but Not the Corresponding 0.1 % Triamcinolone Acetonide Preparations Increase Skin Surface Roughness: A Possible Dissociation of Unwanted Epidermal and Dermal Effects
- 1 January 1996
- journal article
- clinical trial
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 9 (2) , 120-123
- https://doi.org/10.1159/000211407
Abstract
Repeated open application of clobetasol 17-propionate cream and ointment to normal skin over a period of 6 weeks induced an increase in skin surface roughness as assessed by profilometry (p < 0.05), while 6 weeks’ application of triamcinolone acetonide cream and ointment did not. The increase in skin roughness with clobetasol 17-propionate cream turned out to be greater than with ointment containing identical amounts of clobetasol 17-propionate (p < 0.05). A clear-cut correlation between increase of skin surface roughness and skin thickness as assessed by high-frequency ultrasound could be demonstrated only with clobetasol 17-propionate cream and ointment.Keywords
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