Influence of Irradiation Sterilization on Polymers Used as Drug Carriers—A Review
- 1 January 1997
- journal article
- review article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 23 (9) , 857-878
- https://doi.org/10.3109/03639049709148693
Abstract
A survey was made of the influence of irradiation sterilization on relevant natural, semisynthetic, and synthetic polymers used for drug carrier system. The first part of the review deals with some general aspects of irradiation treatment and its use in the sterilization of pharmaceuticals. The second part reviews the information available in the literature on polymeric biomatenals used for carriers after irradiation sterilization. The influence of irradiation sterilization has been described for polyester, poly(ortho ester), different synthetic hydrogels, silicone derivatives, cellulose-derivatives, hyaluronic acid, different glucosides, collagen, and gelatine. Also, some limitations concerning the use of high-energy radiations for sterilization are given.Keywords
This publication has 85 references indexed in Scilit:
- The effect of thermal treatment on sterility, molecular and mechanical properties of various polylactides: I. Poly(l-lactide)Biomaterials, 1996
- Drug release from poly(dl-lactide) microspheres controlled by γ-irradiationJournal of Controlled Release, 1995
- Activity of urea amidohydrolase immobilized within poly[di(methoxyethoxyethoxy)phosphazene] hydrogelsBiomaterials, 1994
- Evaluation of absorbable poly(ortho esters) for use in surgical implantsJournal of Applied Biomaterials, 1994
- In vitro biocompatibility evaluation of a heparinizable material (PUPA), based on polyurethane and poly(amido-amine) componentsBiomaterials, 1994
- The effect of ionizing radiation on lipid membranesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1991
- Thermally Reversible Gelation CharacteristicsPublished by American Chemical Society (ACS) ,1987
- Radiation effects on poly(lactic acid)Polymer, 1983
- Viscosities of Acacia and Sodium Alginate after Sterilization by Cobalt-60Journal of Pharmaceutical Sciences, 1975
- Sterilization problems of synthetic biocompatible materialsJournal of Biomedical Materials Research, 1971