TRANSFER OF TOLERANCE

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Abstract
Immunological tolerance to the male-specific antigen (MSA) system in mice was induced with varying doses of male spleen cells. Dose response “standard” curves for tolerance induction (in neonates) or sensitization (in adults) were established in order to assay by two independent methods the level of persisting MSA in tolerant host spleens. A highly significant and consistent discrepancy in the calculated level of persisting MSA was revealed by these two tests: the tolerance-induction assay consistently gave many-fold higher values of persisting MSA than the sensitization assay. If the sensitization assay is accurate, tolerance transfer to neonatal hosts involves factors in addition to transferred antigen. If the tolerance-induction assay is accurate, there is a selective loss of MSA immunogenicity in tolerant host spleens.
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