Hyperbaric Oxygenation and Renal Ischemia

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Abstract
THE HE CONTINUING search for a suitable method of preserving organs has prompted investigators to combine hyperbaric oxygenation with hypothermia. Humphries and associates1 have perfused isolated dog kidneys with hypothermic solutions for periods of 24 hours under pressures of 3 atmospheres absolute of 100% oxygen. Only one of 34 kidneys subjected to this procedure excreted urine following reimplantation, but it maintained the animal's life for 12 days. Manax et al2 have reported viability of canine kidneys reimplanted after 24 hours of storage. These kidneys were flushed with hypothermic, dextran 40 and then immersed in a balanced salt solution contained within a hyperbaric chamber. The kidneys were not perfused and were maintained at 4 C in 3 atm 100% oxygen for 24 hours. Six dogs survived with reimplanted kidneys following contralateral nephrectomy. More recently, these same authors3 have reported the clinical application of this technique in three patients.

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